Description

(14α)-7,8-Didehydro-4,5α-Epoxy-3-Methoxy-17-Methylmorphinan-6α-Ol is a high-purity, specialized morphinan derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and analytical study of complex opioid alkaloids and their analogs. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical sectors who require precise, well-characterized building blocks for drug discovery, process development, and quality control applications.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of opioid-based active pharmaceutical ingredients (APIs) and novel therapeutic agents.
• Reference Standard: Used as a high-purity calibration standard in analytical laboratories for method development, validation, and quality assurance testing of related compounds.
• Biochemical Research: Employed in pharmacological studies to investigate structure-activity relationships (SAR) and receptor binding mechanisms within the morphinan class.
• Process Chemistry: Utilized in route scouting and optimization for the scalable synthesis of complex molecules in fine chemical and GMP manufacturing.
• Academic Research: Serves as a substrate or reagent in university and institutional research focused on organic synthesis, medicinal chemistry, and neuropharmacology.

Basic Information

Product Name	(14α)-7,8-Didehydro-4,5α-Epoxy-3-Methoxy-17-Methylmorphinan-6α-Ol
CAS No.	16206-70-5
Molecular Formula	C₁₉H₂₃NO₄
Molecular Weight	329.39 g/mol
Synonyms	6α-Hydroxy-3-methoxy-17-methyl-7,8-didehydro-4,5α-epoxymorphinan; 3-O-Methyl-6α-hydroxynaltrexone; 6α-Hydroxy-3-O-methylnaltrexone; 6α-Hydroxy-3-methoxy-17-methylmorphinan-4,5-epoxide; 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol; 3-Methoxy-6α-hydroxynaltrexol; Morphinan-6α-ol, 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methyl-
EINECS	Contact for details

Quality Control

Our (14α)-7,8-Didehydro-4,5α-Epoxy-3-Methoxy-17-Methylmorphinan-6α-Ol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.