Description

[2-[2-[2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy]Ethoxy]Ethoxy]Acetic Acid is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a carboxylic acid end group. This unique structure provides a versatile chemical handle for conjugation, enabling the modification of surfaces, polymers, and biomolecules to impart hydrophilicity, solubility, and biocompatibility. It is an essential intermediate for researchers and manufacturers in pharmaceuticals, advanced materials, and biotechnology who require precise and reliable PEGylation reagents.

Application

• Pharmaceutical PEGylation: A key reagent for covalently attaching polyethylene glycol chains to therapeutic proteins, peptides, and small molecule drugs to improve solubility, extend circulation half-life, and reduce immunogenicity.
• Bioconjugation & Linker Chemistry: Serves as a heterobifunctional linker for coupling biomolecules (e.g., antibodies, enzymes) to other entities like dyes, solid supports, or drug payloads via its reactive acid group.
• Surface Functionalization: Used to create hydrophilic, non-fouling coatings on medical devices, sensors, nanoparticles, and chromatographic media to prevent non-specific protein adsorption.
• Polymer Synthesis & Modification: Acts as a macromonomer or chain-transfer agent in the synthesis of amphiphilic block copolymers, hydrogels, and functional polymers for drug delivery and material science.
• Diagnostic Reagents: Employed in the development of diagnostic assays and imaging probes where stable, water-soluble conjugates are required.
• Cosmetic & Personal Care: Utilized in advanced formulations as a solubilizer, stabilizer, or carrier for active ingredients, enhancing product performance and skin feel.

Basic Information

Product Name	[2-[2-[2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy]Ethoxy]Ethoxy]Acetic Acid
CAS No.	16142-03-3
Molecular Formula	C13H26O9
Molecular Weight	326.34 g/mol
Synonyms	mPEG6-acid; 2,5,8,11,14,17-Hexaoxanonadecan-19-oic acid; α-Methoxy-ω-carboxy hexa(ethylene glycol); Hexaethylene glycol monomethyl ether carboxylic acid; mPEG6-COOH; CH3O-(CH2CH2O)6-CH2COOH; Carboxymethyl hexaethylene glycol methyl ether; PEG6 acid methyl ether
EINECS	Contact for details

Quality Control

Our [2-[2-[2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy]Ethoxy]Ethoxy]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and titration for acid value, to ensure it meets the high standards required for research and cGMP manufacturing. Comprehensive Certificates of Analysis (COA) with full traceability are provided.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at 2-8°C for long-term stability. The product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Acid Value (Titration)	165 - 180 mg KOH/g
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.