Description

4-((Trimethylsilyl)Ethynyl)Benzoic Acid is a versatile organosilicon building block featuring a terminal alkyne protected by a trimethylsilyl (TMS) group and a benzoic acid moiety. This bifunctional structure makes it a critical intermediate for synthesizing complex molecules via cross-coupling reactions like Sonogashira coupling. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel compounds and functionalized polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating acetylene-linked aromatic systems.
• Agrochemical Research: Used in developing new crop protection agents and herbicides where the TMS-protected alkyne allows for selective deprotection and further functionalization.
• Material Science & Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and organic electronic materials.
• Liquid Crystal & OLED Development: Incorporated into the backbone of organic semiconductors and liquid crystal molecules to modify electronic properties and molecular alignment.
• Chemical Biology & Bioconjugation: Utilized as a linker or probe in bioconjugation strategies, leveraging the "click chemistry" compatibility of the alkyne group.
• Organic Synthesis & Catalysis Research: A valuable reagent for academic and industrial research in developing new catalytic methodologies and complex natural product synthesis.

Basic Information

Item	Detail
Product Name	4-((Trimethylsilyl)Ethynyl)Benzoic Acid
CAS No.	16116-80-6
Molecular Formula	C₁₂H₁₄O₂Si
Molecular Weight	218.33 g/mol
Synonyms	4-(Trimethylsilylethynyl)benzoic acid; 4-(2-Trimethylsilylethynyl)benzoic acid; Benzoic acid, 4-[(trimethylsilyl)ethynyl]-; p-((Trimethylsilyl)ethynyl)benzoic acid; 4-(TMS-ethynyl)benzoic acid; 4-Carboxyphenyl(trimethylsilyl)acetylene; (4-Carboxyphenyl)ethynyltrimethylsilane
EINECS	Contact for details

Quality Control

Our production of 4-((Trimethylsilyl)Ethynyl)Benzoic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FT-IR, to ensure high purity and consistent chemical identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters. We support cGMP standards for applications requiring the highest level of quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. The product is light-sensitive and should be stored away from light as indicated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.