Description

6-Chloro-4-Hydroxyquinazoline is a versatile and high-value heterocyclic building block, primarily used in advanced pharmaceutical synthesis and organic chemistry research. Its core value lies in its role as a key intermediate for the development of active pharmaceutical ingredients (APIs), particularly kinase inhibitors and other targeted therapeutics. This compound is essential for R&D chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel compounds with specific biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various kinase inhibitors and other small-molecule drug candidates.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the construction of complex quinazoline-based libraries.
• Agrochemical Research: Serves as a starting material for developing new herbicides, fungicides, and plant growth regulators.
• Biochemical Research: Utilized as a tool compound in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Material Science: Investigated for the development of organic electronic materials and fluorescent dyes due to the quinazoline core structure.

Basic Information

Product Name	6-Chloro-4-Hydroxyquinazoline
CAS No.	16064-14-5
Molecular Formula	C8H5ClN2O
Molecular Weight	180.59 g/mol
Synonyms	4-Hydroxy-6-chloroquinazoline; 6-Chloro-4-quinazolinol; 6-Chloro-4(1H)-quinazolinone; 6-Chloro-4-hydroxyquinazoline; 6-Chloro-4-oxo-3,4-dihydroquinazoline; 6-Chloroquinazolin-4-ol; 6-Chloro-4(3H)-quinazolinone
EINECS	240-207-4

Quality Control

Our 6-Chloro-4-Hydroxyquinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for every batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring the material meets the stringent requirements of advanced R&D and scale-up production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	285 - 290 °C (dec.)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.