Description

4-Methyl-5-Hydroxy-8-Chloroquinoline is a versatile halogenated quinoline derivative that serves as a critical synthetic intermediate and building block in advanced organic chemistry. Its unique molecular structure, featuring both hydroxy and chloro substituents on the quinoline core, makes it a valuable precursor for developing compounds with specialized biological and material properties. This high-purity intermediate is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting infectious diseases or possessing anti-inflammatory properties.
• Agrochemical Research: Used in the development of novel fungicides, herbicides, and plant growth regulators, leveraging its bioactive quinoline scaffold.
• Coordination Chemistry & Ligand Synthesis: Serves as a precursor for creating complexing agents and chelating ligands used in catalysis and metal recovery processes.
• Material Science: Employed in the research of organic electronic materials, dyes, and pigments due to its conjugated aromatic system.
• Chemical Research & Development: A versatile starting material for synthesizing a wide array of more complex quinoline derivatives for various experimental and commercial purposes.

Basic Information

Product Name	4-Methyl-5-Hydroxy-8-Chloroquinoline
CAS No.	16026-78-1
Molecular Formula	C₁₀H₈ClNO
Molecular Weight	193.63 g/mol
Synonyms	8-Chloro-5-hydroxy-4-methylquinoline; 5-Hydroxy-8-chloro-4-methylquinoline; 4-Methyl-8-chloro-5-quinolinol; 8-Chloro-4-methyl-5-quinolinol; 5-Quinolinol, 8-chloro-4-methyl-; 4-Methyl-5-hydroxy-8-chloroquinoline; 16026-78-1 (CAS)
EINECS	Contact for details

Quality Control

Our 4-Methyl-5-Hydroxy-8-Chloroquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet exacting customer specifications. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment, supporting compliance in GMP-aligned applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.