Description

Tetramethyl Methylenediphosphonate is an organophosphorus compound that serves as a versatile chemical intermediate and ligand. This compound is valued for its ability to act as a precursor in the synthesis of complex phosphonates and as a chelating agent in various catalytic systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Used in the synthesis of bisphosphonate drugs and other active pharmaceutical ingredients (APIs) targeting bone metabolism disorders.
• Agrochemical Synthesis: Serves as a key building block for creating novel herbicides, plant growth regulators, and fungicides with phosphonate functional groups.
• Ligand in Catalysis: Acts as a chelating ligand in transition metal catalysis for organic transformations, including cross-coupling and polymerization reactions.
• Flame Retardant Precursor: A starting material in the production of phosphorus-based flame retardants for polymers and textiles.
• Water Treatment Chemical: Utilized in the formulation of scale and corrosion inhibitors for industrial water systems.
• Coordination Chemistry Research: Employed in academic and industrial R&D for studying metal-ligand interactions and developing new metal-organic frameworks (MOFs).
• Surface Modification Agent: Used to functionalize material surfaces with phosphonate groups to alter wettability, adhesion, or biocompatibility.

Basic Information

Product Name	Tetramethyl Methylenediphosphonate
CAS No.	16001-93-7
Molecular Formula	C5H14O6P2
Molecular Weight	232.11 g/mol
Synonyms	Methylenediphosphonic Acid Tetramethyl Ester; Tetramethyl Methanediphosphonate; Dimethyl (Dimethoxophosphoryl)methylphosphonate; Methylene Diphosphonic Acid Tetramethyl Ester; (Methylenebis(phosphonic acid)) tetramethyl ester; TMDP; MDP(O)(OMe)2
EINECS	240-144-5

Quality Control

Our Tetramethyl Methylenediphosphonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.25 g/cm³
Refractive Index (n20D)	~1.445

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.