Description

(E)-β-Chloro-4'-Nitroacrylophenone is a high-purity, light-sensitive chemical building block characterized by its distinct α,β-unsaturated ketone structure. This compound is valued for its role as a versatile electrophilic synthon in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought by research and development laboratories in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those containing nitroaromatic or chalcone-derived pharmacophores.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides, leveraging its reactive acrylophenone core.
• Organic Synthesis Building Block: Serves as a Michael acceptor in conjugate addition reactions and a substrate for nucleophilic substitution at the β-position.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating specialized polymers with unique optical or electronic properties.
• Chemical Biology Probe Development: Utilized to create molecular probes for studying enzyme activity or protein interactions due to its electrophilic warhead.

Basic Information

Product Name	(E)-β-Chloro-4'-Nitroacrylophenone
CAS No.	15787-87-8
Molecular Formula	C9H6ClNO3
Molecular Weight	211.60 g/mol
Synonyms	(E)-3-Chloro-1-(4-nitrophenyl)prop-2-en-1-one; 3-Chloro-1-(4-nitrophenyl)-2-propen-1-one; 4'-Nitro-β-chloroacrylophenone; (E)-β-Chloro-4-nitrochalcone; 1-(4-Nitrophenyl)-3-chloro-2-propen-1-one; NSC 403796; β-Chloro-4'-nitroacrylophenone
EINECS	Contact for details

Quality Control

Our (E)-β-Chloro-4'-Nitroacrylophenone is manufactured under strict quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets exacting research-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under subdued lighting or amber glass when practicable.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.