Description

Z-His-Ome is a protected derivative of the essential amino acid L-Histidine, specifically the Z-protected methyl ester. This compound is a crucial building block in peptide synthesis, offering enhanced stability and solubility for complex coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of histidine residues into peptide chains.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins in solution.
• Pharmaceutical Research: Serves as a precursor in the development of therapeutic peptides targeting various diseases.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for drug delivery and diagnostic applications.
• Chemical Biology Probes: Employed in the synthesis of labeled histidine analogs for studying protein structure and function.
• Catalyst and Ligand Development: The imidazole side chain makes it a valuable scaffold for creating novel metal-chelating ligands and organocatalysts.

Basic Information

Product Name	Z-His-Ome
CAS No.	15545-10-5
Molecular Formula	C15H19N3O5
Molecular Weight	321.33 g/mol
Synonyms	Nα-Carbobenzoxy-L-histidine methyl ester; Z-L-Histidine methyl ester; Cbz-L-Histidine methyl ester; N-Cbz-L-histidine methyl ester; (S)-Methyl 2-(((benzyloxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoate; Benzyl N-[(2S)-3-(1H-imidazol-5-yl)-1-methoxy-1-oxopropan-2-yl]carbamate; Z-His-OMe
EINECS	Contact for details

Quality Control

Our Z-His-Ome is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -12.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.