Description

(4R)-4α,5β-Dimethyl-2-Chloro-1,3,2-Dioxaphospholane is a high-purity, chiral organophosphorus compound used as a key intermediate in advanced chemical synthesis. Its primary value lies in its role as a versatile building block for creating complex molecules with specific stereochemistry, which is critical for developing pharmaceuticals and specialty materials. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for asymmetric synthesis and catalyst development.

Application

• Pharmaceutical Intermediate: A crucial chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting specific biological pathways.
• Ligand and Catalyst Precursor: Used in the preparation of chiral phosphine ligands and metal catalysts for asymmetric hydrogenation and other stereoselective transformations.
• Agrochemical Synthesis: Serves as an intermediate in the production of advanced, stereochemically-defined pesticides and herbicides.
• Material Science Research: Employed in the development of novel polymers and functional materials where phosphorus-containing chiral centers impart specific properties.
• Process Chemistry Development: Used by R&D teams to scale up and optimize synthetic routes for complex molecules in pilot plants.
• Academic and Industrial Research: A valuable reagent for methodological studies in organic synthesis and catalysis within university and corporate R&D laboratories.

Basic Information

Product Name	(4R)-4α,5β-Dimethyl-2-Chloro-1,3,2-Dioxaphospholane
CAS No.	15479-16-0
Molecular Formula	C4H8ClO2P
Molecular Weight	154.53 g/mol
Synonyms	(4R)-4,5-Dimethyl-2-chloro-1,3,2-dioxaphospholane; (R)-4,5-Dimethyl-2-chloro-1,3,2-dioxaphospholane; 2-Chloro-4,5-dimethyl-1,3,2-dioxaphospholane, (4R)-; (4R)-2-Chloro-4,5-dimethyl-1,3,2-dioxaphospholane; Chiral chlorophosphite; Dioxaphospholane chlorophosphite intermediate
EINECS	Contact for details

Quality Control

Our (4R)-4α,5β-Dimethyl-2-Chloro-1,3,2-Dioxaphospholane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including chiral HPLC, NMR, and GC to confirm identity, enantiomeric excess, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance needs for cGMP and other relevant regulatory frameworks upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.