Description

(4Ar)-4A,5,6,7,8,8Aα-Hexahydro-6α-Hydroxy-3,4Aβ,5β-Trimethylnaphtho[2,3-B]Furan-9(4H)-One is a complex, high-purity organic compound belonging to the class of functionalized naphthofurans. This molecule is of significant interest in advanced organic synthesis and pharmaceutical research due to its intricate stereochemistry and functional group array. It serves as a critical chiral intermediate or building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. Target industries include pharmaceutical R&D, contract manufacturing organizations (CMOs), and specialty chemical producers seeking sophisticated synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in steroid-like or terpenoid-based therapeutic areas.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to construct molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Fine Chemical Production: Serves as a precursor for the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereocenters.
• Academic & Industrial R&D: Used in methodological development and as a reference standard in analytical laboratories.

Basic Information

Product Name	(4Ar)-4A,5,6,7,8,8Aα-Hexahydro-6α-Hydroxy-3,4Aβ,5β-Trimethylnaphtho[2,3-B]Furan-9(4H)-One
CAS No.	15401-89-5
Molecular Formula	C₁₈H₂₆O₃
Molecular Weight	290.40 g/mol
Synonyms	6α-Hydroxy-3,4aβ,5β-trimethyl-4a,5,6,7,8,8aα-hexahydronaphtho[2,3-b]furan-9(4H)-one; (4aR,5S,6R,8aR)-5,6,8a-Trimethyl-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3-b]furan-2,9-dione (tautomer); 6α-Hydroxy-3,4aβ,5β-trimethyl-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3-b]furan-9-one; 15401-89-5; NSC 338976; A derivative of Sclareolide.
EINECS	Contact for details

Quality Control

Our production of (4Ar)-4A,5,6,7,8,8Aα-Hexahydro-6α-Hydroxy-3,4Aβ,5β-Trimethylnaphtho[2,3-B]Furan-9(4H)-One adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and chiral purity, NMR, and MS for structural confirmation. We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and research requirements. Specifications are designed to meet the needs of pharmaceutical development and advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.