Description

cis-1,2-Bis(Aminomethyl)Cyclobutane is a versatile bifunctional amine building block featuring a rigid cyclobutane core. This compound is valued for its ability to introduce conformational constraint and dual reactive sites into polymers, pharmaceuticals, and specialty materials. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced polymer industries for applications ranging from linker chemistry to the synthesis of novel macrocycles and ligands.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of constrained peptide mimetics, macrocyclic drugs, and active pharmaceutical ingredients (APIs).
• Polymer & Resin Modifier: Used as a cross-linking agent or chain extender in epoxy, polyurethane, and polyamide resins to enhance thermal and mechanical properties.
• Ligand Synthesis: Employed in the preparation of chelating agents and catalysts for asymmetric synthesis and metal coordination chemistry.
• Agrochemicals: Acts as a building block for creating novel herbicides, fungicides, and plant growth regulators with improved stability.
• Research & Development: A valuable tool for medicinal chemists and material scientists exploring new chemical entities and functional materials.

Basic Information

Product Name	cis-1,2-Bis(Aminomethyl)Cyclobutane
CAS No.	15286-88-1
Molecular Formula	C6H14N2
Molecular Weight	114.19 g/mol
Synonyms	1,2-Cyclobutanedimethanamine, cis-; cis-1,2-Di(aminomethyl)cyclobutane; (1R,2S)-rel-1,2-Bis(aminomethyl)cyclobutane; cis-Cyclobutane-1,2-dimethanamine; 1,2-Bis(aminomethyl)cyclobutane (cis-); NSC 163045; 1,2-Cyclobutanebis(methylamine)
EINECS	Contact for details

Quality Control

Our cis-1,2-Bis(Aminomethyl)Cyclobutane is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay, impurity profile, and physical characteristics are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.