Description

1'-Benzylspiro[Isoquinoline-1(2H),4'-Piperidine]-3(4H)-One Hydrochloride is a high-purity organic salt compound of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or a key pharmacophore in the design of novel therapeutic agents targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new chemical entities (NCEs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies in drug discovery programs.
• Reference Standard: Serves as an analytical standard for quality control and method development in API (Active Pharmaceutical Ingredient) manufacturing.
• Biochemical Research: Potential tool compound for investigating specific biological pathways and receptor interactions in vitro.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to create complex, spirocyclic molecular architectures.

Basic Information

Product Name	1'-Benzylspiro[Isoquinoline-1(2H),4'-Piperidine]-3(4H)-One Hydrochloride
CAS No.	15198-52-4
Molecular Formula	C20H22N2O · HCl
Molecular Weight	342.86 g/mol (Free base: 306.40 g/mol)
Synonyms	1'-Benzylspiro[isoquinoline-1(2H),4'-piperidin]-3(4H)-one hydrochloride; 1'-Benzylspiro[2H-isoquinoline-1,4'-piperidine]-3(4H)-one hydrochloride; 3-Oxo-1'-benzylspiro[2H-isoquinoline-1,4'-piperidine] hydrochloride; Spiro[isoquinoline-1(2H),4'-piperidine]-3(4H)-one, 1'-benzyl-, hydrochloride; 15198-52-4
EINECS	Contact for details

Quality Control

Our 1'-Benzylspiro[Isoquinoline-1(2H),4'-Piperidine]-3(4H)-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant use and a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.