Description

n-Carbobenzoxy-Dl-Norleucine is a protected amino acid derivative, specifically the carbobenzyloxy (Cbz) derivative of DL-norleucine. This compound serves as a crucial building block in peptide synthesis, where the Cbz group acts as a temporary protecting group for the amine functionality. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers involved in the development and production of novel peptides, APIs (Active Pharmaceutical Ingredients), and other bioactive molecules.

Application

• Peptide Synthesis Intermediate: A key raw material in solid-phase and solution-phase peptide synthesis for constructing peptide chains.
• Pharmaceutical Research & Development: Used in the R&D of new therapeutic peptides and protein-based drugs.
• Bioconjugation Chemistry: Employed in the modification of proteins and other biomolecules for drug delivery systems.
• Organic Synthesis Building Block: Serves as a chiral synthon for the preparation of more complex, non-natural amino acids and derivatives.
• Biochemical Research: Utilized in studies of enzyme mechanisms and metabolic pathways involving amino acid analogs.

Basic Information

Product Name	n-Carbobenzoxy-Dl-Norleucine
CAS No.	15027-13-1
Molecular Formula	C₁₄H₁₉NO₄
Molecular Weight	265.31 g/mol
Synonyms	N-Carbobenzyloxy-DL-norleucine; Cbz-DL-Nle-OH; N-(Benzyloxycarbonyl)-DL-norleucine; DL-Norleucine, N-[(benzyloxy)carbonyl]-; Z-DL-Nle-OH; Benzyl N-(1-carboxy-4-pentyl)carbamate; N-Cbz-DL-norleucine; NSC 3349
EINECS	239-107-5

Quality Control

Our n-Carbobenzoxy-Dl-Norleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and synthesis applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	±0.5° (c=1 in DMF)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.