Description

(4-Nitrobenzyl)(Trimethylsilyl) Ether is a specialized organosilicon compound that serves as a versatile protecting group reagent and synthetic intermediate in advanced organic synthesis. Its value lies in the ability of the trimethylsilyl (TMS) group to protect hydroxyl functionalities, while the nitrobenzyl moiety can offer unique reactivity or serve as a photolabile protecting group. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for complex, multi-step synthesis.

Application

• Protecting Group Reagent: Used to introduce the (4-nitrobenzyl)oxy(trimethylsilyl) protecting group for alcohols and phenols in complex molecule synthesis.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where selective deprotection is required.
• Agrochemical Synthesis: Employed in the production of advanced pesticides and herbicides that require silicon-containing intermediates.
• Fine Chemical Manufacturing: Utilized in the preparation of specialty chemicals, dyes, and advanced materials.
• Peptide Chemistry: Can be applied in solid-phase peptide synthesis (SPPS) for side-chain protection strategies.
• Academic & Industrial R&D: A valuable tool for methodological development in organic and medicinal chemistry research laboratories.

Basic Information

Product Name	(4-Nitrobenzyl)(Trimethylsilyl) Ether
CAS No.	14856-73-6
Molecular Formula	C10H15NO3Si
Molecular Weight	225.32 g/mol
Synonyms	4-Nitrobenzyl Trimethylsilyl Ether; Trimethyl[(4-nitrobenzyl)oxy]silane; (4-Nitrobenzyloxy)trimethylsilane; O-[(4-Nitrophenyl)methyl]-O'-trimethylsilanol; TMSONB; 1-[(Trimethylsilyl)oxymethyl]-4-nitrobenzene; (p-Nitrobenzyl)trimethylsilyl Ether
EINECS	Contact for details

Quality Control

Our (4-Nitrobenzyl)(Trimethylsilyl) Ether is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all relevant specifications. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.