Description

Potassium Isobutoxide is a powerful, non-nucleophilic base commonly used in organic synthesis. This compound is critical for driving deprotonation and elimination reactions where a strong, sterically hindered base is required. It is an essential reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to optimize complex synthetic pathways.

Application

• Pharmaceutical Synthesis: Key reagent for the preparation of active pharmaceutical ingredients (APIs), particularly in deprotonation steps and the synthesis of complex heterocycles.
• Polymerization Catalyst: Used as an initiator or catalyst in the production of specialized polymers, including polyethers and elastomers.
• Agrochemical Manufacturing: Employed in the synthesis of advanced pesticides and herbicides, facilitating key bond-forming reactions.
• Fine Chemical Production: Essential for the synthesis of flavors, fragrances, and other high-value specialty chemicals requiring controlled basicity.
• Cross-Coupling Reactions: Acts as a base in transition metal-catalyzed reactions, such as Heck, Suzuki, and Negishi couplings.
• Esterification & Transesterification: Catalyzes ester formation and interchange reactions under mild conditions.
• Chemical Research & Development: A versatile tool in R&D labs for exploring new synthetic methodologies and optimizing reaction conditions.

Basic Information

Product Name	Potassium Isobutoxide
CAS No.	14764-60-4
Molecular Formula	C4H9KO
Molecular Weight	112.21 g/mol
Synonyms	Isobutoxy Potassium; Potassium tert-Butoxide (common misnomer); Potassium 2-Methylpropoxide; Potassium 2-Methyl-1-propoxide; KOiBu; t-BuOK (common misnomer); 2-Methylpropanoic Acid Potassium Salt; Isobutyl Alcohol, Potassium Salt
EINECS	238-812-0

Quality Control

Our Potassium Isobutoxide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and moisture content. Our quality management system is designed to meet the rigorous demands of cGMP and ISO standards for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly hygroscopic and moisture-sensitive nature, this material must be stored under a dry, inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, storage at 2-8°C is recommended. Handle and open containers only in a controlled, moisture-free environment.

Specification

Item	Specification
Appearance	White to off-white powder or lumps
Identification (IR)	Conforms
Assay (Titration)	≥ 95.0 %
Potassium (K) Content	34.0 - 36.0 %
Loss on Drying	≤ 2.0 %
Solubility (in Toluene/THF)	Clear, colorless to slightly yellow solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.