Description

(8Alpha,9R)-9-Chloro-6'-Methoxycinchonan is a high-purity, chiral alkaloid derivative of cinchona, a compound of significant interest in asymmetric synthesis. Its value lies in its role as a versatile chiral building block and ligand for the preparation of advanced pharmaceutical intermediates and catalysts. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-quality, stereochemically defined compounds for process development and scale-up.

Application

• Chiral Ligand Synthesis: A key precursor for the development of cinchona-based organocatalysts used in asymmetric transformations.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) with specific stereochemistry.
• Asymmetric Catalysis Research: Used in academic and industrial R&D to explore new catalytic methodologies for enantioselective synthesis.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals where precise stereocontrol is required.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(8Alpha,9R)-9-Chloro-6'-Methoxycinchonan
CAS No.	14528-48-4
Molecular Formula	C20H23ClN2O2
Molecular Weight	358.86 g/mol
Synonyms	9-Chloro-6'-methoxycinchonan; 9-Chloro-6'-methoxycinchonan-9-ol; (8α,9R)-9-Chloro-6'-methoxycinchonan; Cinchonan-9-ol, 9-chloro-6'-methoxy-, (8α,9R)-; 9-Chloro-6'-methoxycinchonan (8α,9R)-isomer; 9-Chlorocinchonan-6'-methoxy derivative
EINECS	Contact for details

Quality Control

Our (8Alpha,9R)-9-Chloro-6'-Methoxycinchonan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.