Description

n-Acetyl-D-Mannosamine Monohydrate is a high-purity, crystalline monosaccharide derivative that serves as a critical chiral building block and biochemical precursor. Its primary commercial value lies in its role as a key intermediate in the enzymatic and chemical synthesis of sialic acids, including N-acetylneuraminic acid (Neu5Ac). This product is essential for research and production in the pharmaceutical, biotechnology, and diagnostic sectors, where precise control over glycosylation and carbohydrate chemistry is paramount.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sialic acid analogs and glycomimetic drugs targeting influenza, cancer, and inflammatory diseases.
• Bioconjugate Development: Used for the chemical modification of proteins, antibodies, and nanoparticles to improve stability, targeting, and pharmacokinetic properties.
• Enzymatic Synthesis: Serves as a substrate for sialyltransferases in the enzymatic production of oligosaccharides and glycoconjugates for research and therapeutic use.
• Biochemical Research: Fundamental tool in glycolbiology studies for investigating cell-cell recognition, pathogen-host interactions, and glycosylation pathways.
• Diagnostic Reagent Manufacturing: Used in the production of assay components and calibration standards for diagnostic kits related to metabolic disorders and glycosylation defects.
• Nutraceutical & Cosmetic Ingredient: Potential intermediate for advanced bioactive compounds in high-end skincare and nutritional supplement formulations.

Basic Information

Product Name	n-Acetyl-D-Mannosamine Monohydrate
CAS No.	14131-64-7
Molecular Formula	C8H15NO6 • H2O
Molecular Weight	239.22 g/mol
Synonyms	D-Mannosamine, N-acetyl-, monohydrate; N-Acetyl-D-mannosamine monohydrate; ManNAc monohydrate; 2-Acetamido-2-deoxy-D-mannose monohydrate; N-Acetylmannosamine monohydrate; Acetylmannosamine monohydrate; (2R,3S,4R,5R)-2-(Acetylamino)-3,4,5,6-tetrahydroxyhexanal monohydrate; 14131-64-7 (monohydrate)
EINECS	Contact for details

Quality Control

Our n-Acetyl-D-Mannosamine Monohydrate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for pharmaceutical and biochemical applications. Certificates of Analysis (COA) with full traceability are provided, and we support compliance with cGMP, ICH Q7 guidelines, and REACH regulations for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and prevent clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Specific Rotation	+25.0° to +30.0° (c=1 in H2O)
Water Content (KF)	6.0% - 8.5%
Residual Solvents (GC)	Complies with ICH limits
Heavy Metals	≤ 10 ppm
Bacterial Endotoxins	< 0.5 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.