Description

1-(2-Bromoethoxy)-3-Nitrobenzene is a versatile bromoalkyl aryl ether derivative, serving as a critical bifunctional building block in advanced organic synthesis. Its molecular structure, featuring both a reactive bromoethoxy side chain and a nitro-substituted aromatic ring, makes it invaluable for constructing complex molecules through nucleophilic substitution and reduction reactions. This intermediate is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs), ligands, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those requiring phenoxy-ether linkages or aniline derivatives post nitro-group reduction.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and plant growth regulators where its ether bridge facilitates the introduction of specific bioactive moieties.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing chelating ligands used in catalysis and metal complexation studies.
• Polymer and Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced functional materials.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic aromatic substitution (SNAr) reactions due to its reactive halogen and nitro groups.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex azo dyes and other nitro-aromatic based colorants.

Basic Information

Product Name	1-(2-Bromoethoxy)-3-Nitrobenzene
CAS No.	13831-59-9
Molecular Formula	C8H8BrNO3
Molecular Weight	246.06 g/mol
Synonyms	3-Nitrophenyl 2-Bromoethyl Ether; 2-Bromoethyl 3-Nitrophenyl Ether; 1-Bromo-2-(3-nitrophenoxy)ethane; 3-Nitro-1-(2-bromoethoxy)benzene; m-Nitrophenyl 2-Bromoethyl Ether; 2-(3-Nitrophenoxy)ethyl Bromide; 13831-59-9; NSC 406079
EINECS	Contact for details

Quality Control

Our 1-(2-Bromoethoxy)-3-Nitrobenzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and FTIR to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated during use.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.