Description

2-Methyl-2-Propylpropane-1,3-Diyl Dinicotinate is a diester derivative of nicotinic acid (niacin) and a branched-chain diol. This compound serves as a versatile intermediate and functional ingredient, valued for its ability to act as a prodrug or a lipophilic carrier for the controlled delivery of niacin. It is primarily sought by pharmaceutical, nutraceutical, and advanced cosmetic manufacturers for applications requiring enhanced bioavailability and stability of active moieties.

Application

• Pharmaceutical Intermediate: Used in the synthesis of prodrugs designed for sustained or targeted release of niacin, potentially improving patient compliance and reducing side effects like flushing.
• Cosmetic Actives: Functions as a skin-conditioning agent and a precursor to niacinamide in high-performance skincare formulations aimed at improving skin barrier function and appearance.
• Nutraceutical Formulations: Employed in advanced dietary supplement products where enhanced lipid solubility and bioavailability of vitamin B3 are critical.
• Biochemical Research: Serves as a standard or reagent in metabolic studies and research on lipid-soluble vitamin derivatives.
• Polymer Additive: Can be investigated as a plasticizer or functional monomer for specialty polymers requiring specific ester groups.

Basic Information

Product Name	2-Methyl-2-Propylpropane-1,3-Diyl Dinicotinate
CAS No.	13671-63-1
Molecular Formula	C17H22N2O4
Molecular Weight	318.37 g/mol
Synonyms	2-Methyl-2-propyl-1,3-propanediol dinicotinate; 2-Methyl-2-propylpropane-1,3-diyl bis(3-pyridinecarboxylate); 2-Methyl-2-propyltrimethylene dinicotinate; 1,3-Propanediol, 2-methyl-2-propyl-, dinicotinate; Dinicotinic acid ester of 2-methyl-2-propyl-1,3-propanediol; Niacin prodrug intermediate; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 2-Methyl-2-Propylpropane-1,3-Diyl Dinicotinate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for assay and purity, to ensure it meets precise customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We can support development projects requiring compliance with ICH guidelines or other relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.