Description

(1R,2S)-(+)-cis-1-Amino-2-Indanol is a high-purity chiral amino alcohol building block of significant importance in asymmetric synthesis. Its rigid cis-fused bicyclic structure makes it a highly effective chiral auxiliary and ligand for a wide range of catalytic and stoichiometric transformations. This compound is essential for research and production within the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and complex organic molecules requiring precise stereochemical control.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Widely used as a resolving agent and a scaffold for constructing chiral catalysts and ligands.
• Pharmaceutical Intermediate: A key building block in the synthesis of protease inhibitors, including HIV protease inhibitors and renin inhibitors.
• Catalyst and Ligand Precursor: Serves as a starting material for oxazaborolidine catalysts used in enantioselective reductions (e.g., Corey-Bakshi-Shibata catalyst) and other chiral ligands.
• Fine Chemical Synthesis: Employed in the preparation of enantiomerically pure compounds for agrochemicals, flavors, and fragrances.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research.

Basic Information

Product Name	(1R,2S)-(+)-cis-1-Amino-2-Indanol
CAS No.	13630-00-7
Molecular Formula	C9H11NO
Molecular Weight	149.19 g/mol
Synonyms	(1R,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol; (1R,2S)-(+)-1-Aminoindan-2-ol; (+)-cis-1-Amino-2-indanol; (1R,2S)-1-Amino-2-indanol; (1R,2S)-2-Amino-1-indanol; cis-(1R,2S)-1-Amino-2-indanol; Aminoindanol; CBS Reagent Core
EINECS	Contact for details

Quality Control

Our (1R,2S)-(+)-cis-1-Amino-2-Indanol is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. We provide comprehensive analytical data including chiral purity (enantiomeric excess) and standard impurity profiles. Certificates of Analysis (COA) documenting identity, assay, and purity by HPLC are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	88 - 92 °C
Specific Rotation [α]20/D	+40.0° to +44.0° (c=1 in MeOH)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.