Description

2-Oxa-6-Azaspiro[3.3]Heptane, 6-[(4-Methylphenyl)Sulfonyl]- is a high-value, synthetically versatile spirocyclic sulfonamide building block. This compound is critical for medicinal chemistry and pharmaceutical research, serving as a key intermediate in the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate constrained, three-dimensional scaffolds into their molecular designs.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Scaffold: Used to introduce rigid, spirocyclic geometry into lead compounds to improve potency, selectivity, and metabolic stability.
• Agrochemical Synthesis: Serves as an advanced intermediate in the development of new generation herbicides and fungicides with novel modes of action.
• Chemical Biology Probe Development: Employed in the synthesis of tool compounds for target validation and pathway analysis in biological systems.
• Ligand and Catalyst Development: Used as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	2-Oxa-6-Azaspiro[3.3]Heptane, 6-[(4-Methylphenyl)Sulfonyl]-
CAS No.	13573-28-9
Molecular Formula	C12H15NO3S
Molecular Weight	253.32 g/mol
Synonyms	6-(p-Toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane; 6-(Tosyl)-2-oxa-6-azaspiro[3.3]heptane; 2-Oxa-6-azaspiro[3.3]heptane-6-sulfonic acid (4-methylphenyl) ester; Tosyl-2-oxa-6-azaspiro[3.3]heptane; 6-(4-Methylbenzenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane; Spirocyclic Tosylamide; Azaspiroheptane Sulfonamide Derivative
EINECS	Contact for details

Quality Control

Our 2-Oxa-6-Azaspiro[3.3]Heptane, 6-[(4-Methylphenyl)Sulfonyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. For advanced applications, we offer material produced under cGMP guidelines and can support regulatory filings with full traceability documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.