Description

1-(2,2,2-Trifluoroethyl)Piperazine Dihydrochloride is a high-purity, fluorinated piperazine derivative supplied as a stable dihydrochloride salt. This compound serves as a critical pharmaceutical intermediate and versatile building block in advanced organic synthesis, enabling the introduction of a trifluoroethyl-piperazine moiety into target molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the trifluoroethyl group for enhanced activity.
• Chemical Research & Development: A versatile reagent for constructing complex nitrogen-containing heterocycles and fluorinated compounds in medicinal chemistry.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science: Potential intermediate in the synthesis of advanced polymers and specialty chemicals with unique fluorinated properties.

Basic Information

Product Name	1-(2,2,2-Trifluoroethyl)Piperazine Dihydrochloride
CAS No.	13349-91-2
Molecular Formula	C6H12Cl2F3N2
Molecular Weight	237.07 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride; 1-(Trifluoroethyl)piperazine dihydrochloride; N-(2,2,2-Trifluoroethyl)piperazine dihydrochloride; Piperazine, 1-(2,2,2-trifluoroethyl)-, dihydrochloride; 13349-91-2; 1-Trifluoroethylpiperazine dihydrochloride; 1-(2,2,2-Trifluoroethyl)piperazine hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoroethyl)Piperazine Dihydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.