Description

Benzo(A)Pyrene 7,8-Dihydrodiol is a crucial dihydrodiol metabolite of the environmental pollutant and potent carcinogen Benzo[a]pyrene (BaP). This compound matters significantly as a key intermediate in the metabolic activation pathway of BaP, making it an essential reference standard and research tool for toxicological and metabolic studies. Researchers in pharmaceutical development, environmental safety, and analytical chemistry need it to investigate carcinogenesis mechanisms, calibrate analytical instruments, and develop detection methods for polycyclic aromatic hydrocarbon (PAH) exposure and bioactivation.

Application

• Biochemical Research: Used as a critical intermediate in studying the metabolic activation pathways of Benzo[a]pyrene and its DNA-adduct forming potential.
• Toxicology & Carcinogenicity Studies: Serves as a reference standard in assays designed to understand the mechanisms of PAH-induced carcinogenesis.
• Analytical Reference Standard: Essential for the calibration of HPLC, GC-MS, and LC-MS systems in environmental, food, and biological monitoring for PAH metabolites.
• Pharmaceutical Development: Utilized in research focused on chemoprevention and the development of compounds that inhibit the metabolic activation of procarcinogens.
• Environmental Science: Employed in studies assessing human exposure to PAHs through biomonitoring and risk assessment models.
• Enzyme Activity Assays: Acts as a substrate for studying the activity of cytochrome P450 enzymes and epoxide hydrolase involved in xenobiotic metabolism.

Basic Information

Product Name	Benzo(A)Pyrene 7,8-Dihydrodiol
CAS No.	13345-25-0
Molecular Formula	C₂₀H₁₄O₂
Molecular Weight	286.32 g/mol
Synonyms	Benzo[a]pyrene-7,8-dihydrodiol; 7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene; (±)-Benzo[a]pyrene-7,8-diol; BP-7,8-diol; BaP-7,8-dihydrodiol; trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene; 7,8-Dihydrobenzo[a]pyrene-7,8-diol; Benzo[a]pyrene 7,8-diol
EINECS	Contact for details

Quality Control

Our Benzo(A)Pyrene 7,8-Dihydrodiol is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for reference materials, and specifications can be tailored to meet specific research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, store desiccated at 2-8°C. Allow the container to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, methanol, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.