Description

1-Hydroxybenzo(A)Pyrene is a monohydroxylated derivative of the polycyclic aromatic hydrocarbon benzo(a)pyrene, a compound of significant environmental and toxicological interest. This metabolite is a critical reference standard and research chemical for studying the metabolic activation pathways, DNA adduct formation, and carcinogenic mechanisms associated with PAH exposure. It is essential for analytical laboratories, environmental monitoring agencies, and research institutions focused on toxicology, biomarker discovery, and regulatory compliance testing.

Application

• Analytical Reference Standard: Primary use as a high-purity certified reference material (CRM) for the calibration of analytical instruments like HPLC, GC-MS, and LC-MS in environmental and biological monitoring.
• Toxicology & Metabolic Studies: Crucial for in vitro and in vivo research investigating the metabolic pathways, bioactivation, and detoxification of benzo(a)pyrene and related PAHs.
• Biomarker Research: Used in the development and validation of analytical methods for detecting PAH metabolites (e.g., 1-OH-BaP) as biomarkers of exposure in human biomonitoring studies.
• Environmental Analysis: Serves as a standard for quantifying PAH derivatives in complex matrices such as soil, water, air particulates, and food products.
• DNA Adduct Formation Studies: Employed in research to understand and quantify the covalent binding of activated PAH metabolites to DNA, a key event in chemical carcinogenesis.
• Quality Control & Method Development: Essential for pharmaceutical and contract research organizations (CROs) to develop, validate, and ensure the accuracy of analytical methods for impurity profiling and safety assessment.

Basic Information

Product Name	1-Hydroxybenzo(A)Pyrene
CAS No.	13345-23-8
Molecular Formula	C₂₀H₁₂O
Molecular Weight	268.31 g/mol
Synonyms	1-Hydroxybenzo[a]pyrene; 1-OH-BaP; 1-Hydroxy-BaP; Benzo[a]pyren-1-ol; 1-HBP; 1-Hydroxy-3,4-benzpyrene; Hydroxybenzo(a)pyrene; PAH Metabolite Standard
EINECS	Contact for details

Quality Control

Our 1-Hydroxybenzo(A)Pyrene is manufactured and handled under strict quality protocols to ensure identity, purity, and stability for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chromatographic data, and spectroscopic confirmation. We support compliance with relevant Good Laboratory Practice (GLP) and ISO guidelines for reference materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or COA. For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep the container in a dry, cool, and well-ventilated place. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown powder or crystals
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.