Description

2α,5α-Dimethoxytetrahydrofuran is a versatile heterocyclic ether and a protected form of a dihydroxy carbonyl compound, widely recognized by its CAS registry number 13269-48-2. This specialty chemical serves as a crucial synthetic intermediate and protecting group reagent, enabling complex organic transformations with high selectivity. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for the development of active ingredients and novel molecular entities.

Application

• Pharmaceutical Synthesis: Key intermediate in the production of nucleoside analogs, antiviral drugs, and other active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a building block for fragrances, flavors, and specialty polymers.
• Academic & Industrial R&D: A valuable reagent in organic chemistry research for constructing complex heterocycles and chiral molecules.
• Chemical Protecting Group: Utilized to protect diol or carbonyl functionalities during multi-step synthetic sequences.

Basic Information

Product Name	2α,5α-Dimethoxytetrahydrofuran
CAS No.	13269-48-2
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	2,5-Dimethoxytetrahydrofuran; 2,5-Dimethoxyoxolane; Tetrahydro-2,5-dimethoxyfuran; 2,5-Dimethoxy-tetrahydro-furan; NSC 5235; 1,4-Dimethoxybutane-1,4-diol cyclic acetal; Furan, tetrahydro-2,5-dimethoxy-
EINECS	Contact for details

Quality Control

Our 2α,5α-Dimethoxytetrahydrofuran is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, maintaining an inert atmosphere (e.g., under nitrogen or argon) is recommended to preserve stability and purity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.415 - 1.425
Density (g/mL, 20°C)	1.020 - 1.050

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.