Description

(S)-4-Hydroxymandelic Acid is a high-purity chiral building block and intermediate of significant importance in asymmetric synthesis. Its value lies in its enantiomeric purity, which is critical for producing optically active pharmaceuticals and fine chemicals. This compound is essential for research and manufacturing in the pharmaceutical, agrochemical, and specialty chemical industries, where it serves as a precursor for active pharmaceutical ingredients (APIs) and complex molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiomerically pure drugs, particularly β-blockers and other cardiovascular or neurological agents.
• Asymmetric Synthesis: Used as a starting material or resolving agent in catalytic asymmetric reactions to construct complex molecular architectures.
• Fine Chemical Production: Serves as a building block for advanced materials, ligands for catalysts, and specialty polymers.
• Biochemical Research: Employed in enzymatic studies and as a standard for analytical method development in chiral separations.
• Agrochemical Synthesis: Intermediate for developing chiral pesticides and herbicides with improved efficacy and environmental profiles.

Basic Information

Product Name	(S)-4-Hydroxymandelic Acid
CAS No.	13244-75-2
Molecular Formula	C8H8O5
Molecular Weight	184.15 g/mol
Synonyms	(S)-(-)-4-Hydroxymandelic Acid; (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetic Acid; L-4-Hydroxymandelic Acid; (S)-4-Hydroxy-α-hydroxyphenylacetic Acid; 4-Hydroxy-L-mandelic Acid; (S)-α,4-Dihydroxybenzeneacetic Acid; (2S)-2-Hydroxy-2-(4-hydroxyphenyl)ethanoic Acid; (S)-HMA
EINECS	Contact for details

Quality Control

Our (S)-4-Hydroxymandelic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider storing under an inert atmosphere such as nitrogen or argon in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.