Description

4-Methylbenzene-1-Carboxylic Anhydride is a high-purity organic acid anhydride, a key reactive intermediate in fine chemical synthesis. Its value lies in its role as an efficient acylating agent for introducing the p-toluoyl group, enabling the production of advanced materials and active pharmaceutical ingredients. This compound is essential for R&D and manufacturing in the pharmaceutical, agrochemical, and specialty polymer industries.

Application

• Pharmaceutical Intermediate: Acylating agent in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs.
• Agrochemical Synthesis: Key building block for manufacturing herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Monomer or modifier in the production of specialty polyimides, polyesters, and epoxy curing agents.
• Dye and Pigment Manufacturing: Intermediate for synthesizing advanced organic colorants and photoinitiators.
• Liquid Crystal & OLED Materials: Used in the synthesis of aromatic cores for electronic display materials.
• Organic Synthesis Reagent: Versatile reagent for laboratory-scale acylation reactions and protecting group chemistry.

Basic Information

Product Name	4-Methylbenzene-1-Carboxylic Anhydride
CAS No.	13222-85-0
Molecular Formula	C16H14O3
Molecular Weight	254.28 g/mol
Synonyms	p-Toluic Anhydride; 4-Methylbenzoic Anhydride; p-Toluoyl Anhydride; p-Methylbenzoic Anhydride; Toluene-4-carboxylic acid anhydride; Di-p-toluoyl anhydride; Bis(4-methylbenzoyl) anhydride; Anhydride p-toluique (French)
EINECS	Contact for details

Quality Control

Our 4-Methylbenzene-1-Carboxylic Anhydride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for industrial and research applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent hydrolysis. Keep away from strong bases, strong oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.