Description

Hyperforin is a major prenylated phloroglucinol derivative and a key bioactive constituent of St. John's wort (*Hypericum perforatum* L.). This compound is of significant commercial and research interest due to its unique biological profile, which includes potent antidepressant, antibacterial, and anti-inflammatory activities. It is primarily utilized by the pharmaceutical, nutraceutical, and research sectors for the development of standardized botanical extracts, active pharmaceutical ingredients (APIs), and as a critical reference standard in analytical chemistry.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of standardized botanical extracts for mood support and antidepressant preparations.
• Nutraceutical & Dietary Supplements: Used as a marker compound to standardize and ensure the potency and quality of St. John's wort extract supplements.
• Biomedical & Pharmacological Research: Serves as a critical reference standard and investigational compound for studying mechanisms of neurotransmitter reuptake inhibition, antibacterial effects, and anti-cancer properties.
• Analytical Chemistry: Employed as a high-purity certified reference material (CRM) for HPLC, LC-MS, and other analytical methods to quantify hyperforin content in raw materials and finished products.
• Cosmeceutical Formulations: Investigated for use in topical applications targeting skin inflammation and bacterial infections due to its anti-inflammatory and antimicrobial activity.

Basic Information

Product Name	Hyperforin
CAS No.	11079-53-1
Molecular Formula	C35H52O4
Molecular Weight	536.78 g/mol
Synonyms	Hyperforin; 1,3,4,6-Tetrahydroxy-5-(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)-4,6-bis(3-methylbut-2-en-1-yl)cyclohexa-2,4-dien-1-one; 4-Hydroxy-2-methyl-4-(3,7-dimethylocta-2,6-dien-1-yl)-6-(3-methylbut-2-en-1-yl)-3-(2-methylpropanoyl)cyclohexa-2,5-dien-1-one; Hyperforine; Hypericum perforatum extract constituent; NSC 720579
EINECS	Contact for details

Quality Control

Our Hyperforin is produced and tested under strict quality management systems to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical testing including HPLC for assay and related substances, IR for identification, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each batch to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow amorphous powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.