Description

4-Ethynyl-Benzoic Acid is a versatile aromatic carboxylic acid derivative featuring a terminal alkyne functional group, making it a valuable bifunctional building block in synthetic chemistry. Its core value lies in enabling the construction of complex molecular architectures through robust coupling reactions like Sonogashira and click chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for drug discovery, ligand synthesis, and polymer development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in oncology and CNS drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a monomer or cross-linker for creating specialized polymers, dendrimers, and metal-organic frameworks (MOFs).
• Bioconjugation & Probes: The alkyne group enables efficient labeling of biomolecules (proteins, nucleic acids) via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Ligand & Catalyst Development: Used to prepare sophisticated ligands for catalysis and molecular recognition applications.
• Organic Electronic Materials: A precursor for conjugated systems used in OLEDs, OFETs, and other optoelectronic devices.

Basic Information

Product Name	4-Ethynyl-Benzoic Acid
CAS No.	10602-00-3
Molecular Formula	C9H6O2
Molecular Weight	146.14 g/mol
Synonyms	4-Ethynylbenzoic Acid; Benzoic acid, 4-ethynyl-; p-Ethynylbenzoic Acid; 4-Carboxyphenylacetylene; (4-Carboxyphenyl)ethyne; 4-Ethynylbenzenecarboxylic acid; 10602-00-3; p-Carboxyphenylacetylene
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	210 - 215 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.