Description

2-[(1S,2R,5R)-1,2-Dimethylbicyclo[3.1.0]Hex-2-Yl]-5-Methylphenol is a high-purity, stereochemically defined phenolic compound with a unique bicyclic terpene-derived structure. This compound is valued for its role as a critical chiral intermediate and building block in advanced organic synthesis, particularly for pharmaceuticals and fine chemicals. It is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce complex, rigid molecular frameworks with precise stereochemistry.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where its bicyclic structure can contribute to unique biological activity.
• Fine Chemical Production: Serves as a precursor for fragrances, flavors, and other high-value specialty chemicals requiring specific stereoisomers.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specialized thermal or mechanical properties.
• Catalyst Ligand Development: Potential framework for developing novel chiral ligands used in asymmetric catalysis.
• Academic & Industrial R&D: A valuable reference standard and starting material for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	2-[(1S,2R,5R)-1,2-Dimethylbicyclo[3.1.0]Hex-2-Yl]-5-Methylphenol
CAS No.	10539-88-5
Molecular Formula	C15H20O
Molecular Weight	216.32 g/mol
Synonyms	(1S,2R,5R)-1,2-Dimethyl-3-(5-methyl-2-hydroxyphenyl)bicyclo[3.1.0]hexane; 2-[(1S,2R,5R)-1,2-Dimethyl-3-bicyclo[3.1.0]hexyl]-5-methylphenol; (-)-2-(1,2-Dimethylbicyclo[3.1.0]hex-2-yl)-5-methylphenol; Phenol, 2-[(1S,2R,5R)-1,2-dimethyl-3-bicyclo[3.1.0]hexyl]-5-methyl-; Terpene-derived phenol chiral intermediate
EINECS	Contact for details

Quality Control

Our 2-[(1S,2R,5R)-1,2-Dimethylbicyclo[3.1.0]Hex-2-Yl]-5-Methylphenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and isomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.