Description

(3α,5β,7α)-3,7-Dihydroxy-12-Oxocholan-24-Oic Acid Methyl Ester is a high-purity steroidal derivative, specifically a methylated bile acid analog, that serves as a critical intermediate in advanced pharmaceutical synthesis. Its precise stereochemistry and functional groups make it an invaluable building block for the research and development of novel therapeutic agents targeting metabolic and liver-related pathways. This compound is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in steroid chemistry, drug discovery, and metabolic studies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Drug Discovery & Research: Used as a reference standard and precursor in medicinal chemistry programs focused on developing drugs for liver diseases, cholesterol regulation, and metabolic disorders.
• Biochemical Research: Employed in studies investigating bile acid metabolism, receptor interactions (e.g., FXR, TGR5), and related signaling pathways.
• Fine Chemical Synthesis: Serves as a starting material or intermediate for the custom synthesis of specialized steroidal compounds for analytical and diagnostic applications.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and compound identification via HPLC, LC-MS, or NMR.

Basic Information

Product Name	(3α,5β,7α)-3,7-Dihydroxy-12-Oxocholan-24-Oic Acid Methyl Ester
CAS No.	10538-64-4
Molecular Formula	C₂₅H₄₀O₆
Molecular Weight	436.59 g/mol
Synonyms	Methyl 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate; 3α,7α-Dihydroxy-12-oxo-5β-cholan-24-oic Acid Methyl Ester; 12-Oxochenodeoxycholic Acid Methyl Ester; Methyl 12-Oxochenodeoxycholate; 12-Oxo-CDCA Methyl Ester; 12-Ketochenodeoxycholic Acid Methyl Ester; 12-Oxolithocholic Acid Methyl Ester Derivative
EINECS	Contact for details

Quality Control

Our (3α,5β,7α)-3,7-Dihydroxy-12-Oxocholan-24-Oic Acid Methyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.