Description

Tris(Trimethylsilyl)Phosphate (CAS NO 10497-05-9) is a versatile organosilicon reagent primarily used as a powerful phosphorylating and silylating agent in advanced organic synthesis. Its significance lies in its ability to introduce phosphate and trimethylsilyl protecting groups simultaneously, facilitating complex molecular constructions. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the phosphorylation of nucleosides, nucleotides, and other biologically active molecules in antiviral and anticancer drug development.
• Agrochemical Production: Used in the synthesis of organophosphate-based pesticides, herbicides, and plant growth regulators.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the production of specialty silicones, flame-retardant polymers, and surface-modifying coatings.
• Peptide Chemistry: Employed for the protection of phosphate groups in solid-phase peptide synthesis (SPPS) and the preparation of phosphopeptides.
• Catalysis & Ligand Preparation: Serves as a precursor for catalysts and ligands used in asymmetric synthesis and transition metal catalysis.
• Analytical Chemistry: Utilized as a derivatization agent in gas chromatography (GC) and mass spectrometry (MS) for the analysis of compounds containing acidic hydrogens.

Basic Information

Product Name	Tris(Trimethylsilyl)Phosphate
CAS No.	10497-05-9
Molecular Formula	C9H27O4PSi3
Molecular Weight	314.53 g/mol
Synonyms	Phosphoric Acid Tris(trimethylsilyl) Ester; Tris(O-trimethylsilyl) Phosphate; Tris(trimethylsilyl) Phosphate; TMS-Phosphate; Trimethylsilyl Phosphate; Tris(trimethylsiloxy)phosphine Oxide; O,O,O-Tris(trimethylsilyl) Phosphate
EINECS	234-013-5

Quality Control

Our Tris(Trimethylsilyl)Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, GC, and HPLC, to ensure high chemical purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.