Description

Ethyl 4,4-Diethoxy-3-Oxobutanoate is a versatile acetoacetate derivative and a key protected form of ethyl acetoacetate. This compound is a crucial synthetic intermediate in organic chemistry, prized for its reactive β-keto ester functionality masked by acetal protection. It is primarily sought by research and development chemists in the pharmaceutical and fine chemical industries for constructing complex molecular architectures, including heterocycles and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of various drug molecules, including potential candidates for central nervous system (CNS) agents and anti-inflammatory drugs.
• Fine Chemical Synthesis: Used in the production of complex organic compounds, dyes, and pigments where selective reactivity is required.
• Agrochemical Research: Serves as a precursor in developing novel pesticides and herbicides due to its modifiable reactive sites.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, particularly in reactions involving carbanion chemistry and cyclizations.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing specific aroma chemicals and esters.
• Polymer Chemistry: Can be utilized as a monomer or cross-linking agent in specialty polymer formulations.

Basic Information

Product Name	Ethyl 4,4-Diethoxy-3-Oxobutanoate
CAS No.	10495-09-7
Molecular Formula	C10H18O5
Molecular Weight	218.25 g/mol
Synonyms	Ethyl 3-Oxo-4,4-diethoxybutyrate; Diethyl Acetal of Ethyl Acetoacetate; Ethyl 4,4-Diethoxyacetoacetate; 4,4-Diethoxy-3-oxobutanoic Acid Ethyl Ester; 3-Oxobutanoic Acid, 4,4-Diethoxy-, Ethyl Ester; Ethyl (4,4-Diethoxy-3-oxo)butyrate; Acetoacetic Ester Diethyl Acetal; EAA Diethyl Acetal
EINECS	234-001-9

Quality Control

Our Ethyl 4,4-Diethoxy-3-Oxobutanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (IR, NMR), to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.420 - 1.430
Density (g/mL, 20°C)	1.040 - 1.080

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.