Description

4-Chloro-3-Hydroxy-Butyricacidmethylester is a versatile chiral building block and key synthetic intermediate in organic chemistry. Its value lies in the presence of multiple functional groups—chloro, hydroxy, and ester—which allow for selective transformations, making it a crucial precursor for complex molecule synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of β-blockers, statins, and other cardiovascular or central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that require specific stereochemistry.
• Fine Chemical Production: Serves as a building block for fragrances, flavors, and advanced materials where precise molecular architecture is required.
• Academic & R&D: Employed in methodological development and asymmetric synthesis research within university and industrial laboratories.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	4-Chloro-3-Hydroxy-Butyricacidmethylester
CAS No.	10488-68-3
Molecular Formula	C5H9ClO3
Molecular Weight	152.57 g/mol
Synonyms	Methyl 4-Chloro-3-hydroxybutyrate; (R/S)-Methyl 4-Chloro-3-hydroxybutyrate; 4-Chloro-3-hydroxybutyric acid methyl ester; 3-Hydroxy-4-chlorobutyric acid methyl ester; CHBM; Methyl (3R)-4-chloro-3-hydroxybutanoate; Methyl (3S)-4-chloro-3-hydroxybutanoate; γ-Chloro-β-hydroxybutyric acid methyl ester
EINECS	234-004-4

Quality Control

Our production of 4-Chloro-3-Hydroxy-Butyricacidmethylester adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques like GC, HPLC, and NMR to ensure identity, purity, and chiral integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality system is designed to support applications requiring high standards, including cGMP manufacturing for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere if opened for prolonged use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.