Description

trans-1-Hydroxyquinolizidine is a versatile chiral piperidine alkaloid derivative, serving as a crucial building block in advanced organic synthesis. Its value lies in its rigid bicyclic structure and functional handle, which are essential for constructing complex molecules with high stereochemical control. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and novel chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of bioactive alkaloids and potential drug candidates targeting neurological and cardiovascular systems.
• Asymmetric Catalyst Ligand Precursor: Used in the development of novel chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Agrochemical Research: Serves as a structural motif in the design and synthesis of new pesticides and herbicides with specific modes of action.
• Chemical Biology Probe: Utilized in medicinal chemistry to explore structure-activity relationships (SAR) and enzyme inhibition.
• Academic & R&D: Fundamental research in organic methodology development and natural product synthesis.
• Flavor & Fragrance Chemistry: Potential intermediate for creating complex, nitrogen-containing aroma chemicals.

Basic Information

Product Name	trans-1-Hydroxyquinolizidine
CAS No.	10447-20-8
Molecular Formula	C9H17NO
Molecular Weight	155.24 g/mol
Synonyms	(1R,9aR)-Octahydro-2H-quinolizine-1-ol; (1R,9aR)-1-Hydroxyquinolizidine; (-)-trans-1-Hydroxyquinolizidine; 1-Hydroxyquinolizidine, trans-; Quinolizidin-1-ol; 1-Quinolizidinol; trans-Octahydro-2H-quinolizine-1-ol
EINECS	Contact for details

Quality Control

Our trans-1-Hydroxyquinolizidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific analytical results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.