Description

H-Dab(Z)-Ome Hcl is a protected amino acid derivative, specifically the hydrochloride salt of the Z-protected form of 2,4-diaminobutyric acid methyl ester. This compound serves as a critical building block in the synthesis of complex peptides and peptidomimetics, where precise control over side-chain functionality is essential. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in developing novel therapeutic agents and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for incorporating the diaminobutyric acid (Dab) residue with orthogonal side-chain protection.
• Antibiotic Research: Used in the synthesis of peptide-based antibiotics and antimicrobial agents that target bacterial cell walls.
• Peptidomimetic Drug Design: Serves as a scaffold for creating metabolically stable analogs of natural peptides for enhanced therapeutic profiles.
• Bioconjugation Chemistry: The free amine group, after deprotection, can be used for linking peptides to other molecules, dyes, or solid supports.
• Chemical Biology Probes: Employed in the construction of labeled peptides for studying protein-protein interactions and enzyme mechanisms.
• Custom Peptide Services: A fundamental reagent for contract research organizations (CROs) and CDMOs producing bespoke peptide sequences for clients.

Basic Information

Product Name	H-Dab(Z)-Ome Hcl
CAS No.	10270-79-8
Molecular Formula	C14H21N2O4 • HCl
Molecular Weight	308.79 g/mol (Free base: 272.32 g/mol)
Synonyms	H-Dab(Z)-OMe•HCl; Methyl N2-[(benzyloxy)carbonyl]-L-2,4-diaminobutanoate hydrochloride; L-2,4-Diaminobutyric acid N2-Z-methyl ester hydrochloride; Z-Dab-OMe hydrochloride; (S)-Methyl 2-(((benzyloxy)carbonyl)amino)-4-aminobutanoate hydrochloride; Nα-Z-L-2,4-diaminobutyric acid methyl ester hydrochloride; Methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-4-aminobutanoate hydrochloride
EINECS	Contact for details

Quality Control

Our H-Dab(Z)-Ome Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.