Description

Triethyl 4-Phosphonocrotonate is a high-purity organophosphorus compound, specifically a phosphonate ester, widely recognized as a key Horner-Wadsworth-Emmons (HWE) reagent. Its primary value lies in its exceptional utility as a stabilized ylide precursor for the stereoselective synthesis of α,β-unsaturated esters, a fundamental transformation in fine chemical and pharmaceutical manufacturing. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for constructing key olefinic fragments in active pharmaceutical ingredients (APIs) via the Horner-Wadsworth-Emmons olefination reaction.
• Agrochemical Production: Used in the synthesis of complex molecules for crop protection agents, including fungicides and herbicides.
• Fine Chemical Manufacturing: Serves as a versatile building block for producing specialty chemicals, flavors, and fragrances.
• Material Science Research: Employed in the development of novel polymers and organic electronic materials that require specific olefinic linkages.
• Academic & R&D Laboratories: A staple reagent for methodological development in organic synthesis and catalysis studies.
• Process Chemistry: Valued for its stability and predictable reactivity in scaling up synthetic routes from lab to pilot plant.

Basic Information

Product Name	Triethyl 4-Phosphonocrotonate
CAS No.	10236-14-3
Molecular Formula	C10H19O5P
Molecular Weight	250.23 g/mol
Synonyms	Triethyl (E)-4-phosphonocrotonate; (E)-Triethyl 4-phosphonocrotonate; Diethyl [(E)-2-ethoxycarbonylvinyl]phosphonate; Diethyl (2-carboxyvinyl)phosphonate triethyl ester; (E)-Diethyl (2-ethoxycarbonylvinyl)phosphonate; 4-Phosphonocrotonic acid triethyl ester; HWE Reagent for crotonate; Triethyl phosphonocrotonate
EINECS	233-575-6

Quality Control

Our Triethyl 4-Phosphonocrotonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and isomeric composition, NMR for structural confirmation, and GC for residual solvent analysis to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
(E)-Isomer Content	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.