Description

(1'R)-1'-Acetyl-2',3',8',8'A-Tetrahydro-5'-Ethoxy-6'-Methoxyspiro[2,5-Cyclohexadiene-1,7'(1'H)-Cyclopent[Ij]Isoquinolin]-4-One is a complex, high-purity spirocyclic organic compound of significant interest in advanced synthetic chemistry. This molecule serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block for the development of novel bioactive compounds. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of specialized alkaloids and heterocyclic targets.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of potential therapeutic agents, particularly those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Alkaloid Synthesis: Serves as a core structural unit for the construction of complex isoquinoline and related natural product analogs.
• Asymmetric Synthesis: Employed in chiral pool synthesis and as a starting material for generating enantiomerically pure compounds due to its defined (1'R) stereochemistry.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and receptor interactions.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	(1'R)-1'-Acetyl-2',3',8',8'A-Tetrahydro-5'-Ethoxy-6'-Methoxyspiro[2,5-Cyclohexadiene-1,7'(1'H)-Cyclopent[Ij]Isoquinolin]-4-One
CAS No.	10214-74-1
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	1'-Acetyl-2',3',8',8'a-tetrahydro-5'-ethoxy-6'-methoxyspiro[cyclohexa-2,5-diene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one; Spiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinoline]-4-one, 1'-acetyl-2',3',8',8'a-tetrahydro-5'-ethoxy-6'-methoxy-, (1'R)-; (R)-1'-Acetyl-2',3',8',8'a-tetrahydro-5'-ethoxy-6'-methoxyspiro[cyclohexa-2,5-diene-1,7'-cyclopent[ij]isoquinolin]-4-one; CAS 10214-74-1
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical synthetic steps. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chiral purity (HPLC), chemical purity (HPLC), and residual solvents (GC). Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere if specified. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.