Description

(1S)-2',3',8',8'Aβ-Tetrahydro-5',6'-Dimethoxy-1'-Methylspiro[2-Cyclohexene-1,7'(1'H)-Cyclopenta[Ij]Isoquinoline]-4-One is a complex spirocyclic alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block and key intermediate for the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of complex natural product analogs and the exploration of new therapeutic agents targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, particularly those with complex polycyclic frameworks.
• Organic Synthesis Research: Used as a sophisticated building block for constructing spirocyclic and isoquinoline-based compound libraries in medicinal chemistry.
• Natural Product Analog Synthesis: Serves as a core structure for synthesizing analogs of naturally occurring alkaloids for biological activity screening.
• Chemical Reference Standard: Employed as a high-purity analytical standard for method development and quality control in research laboratories.
• Asymmetric Catalysis Studies: Utilized as a substrate or ligand precursor in the development of new asymmetric synthetic methodologies.
• Neuroscience Research: Investigated for its potential interaction with biological targets relevant to neurological pathways.

Basic Information

Item	Details
Product Name	(1S)-2',3',8',8'Aβ-Tetrahydro-5',6'-Dimethoxy-1'-Methylspiro[2-Cyclohexene-1,7'(1'H)-Cyclopenta[Ij]Isoquinoline]-4-One
CAS No.	10214-56-9
Molecular Formula	C₂₁H₂₅NO₃
Molecular Weight	339.43 g/mol
Synonyms	(1S)-1'-Methylspiro[2-cyclohexene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-2',3',8',8'a-tetrahydro-5',6'-dimethoxy-4-one; (S)-1'-Methylspiro[2-cyclohexene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-2',3',8',8'a-tetrahydro-5',6'-dimethoxy-4-one; Spiro[2-cyclohexene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one, 2',3',8',8'a-tetrahydro-5',6'-dimethoxy-1'-methyl-, (1S)-; 10214-56-9; (1S)-1'-Methyl-5',6'-dimethoxyspiro[2-cyclohexene-1,7'-cyclopenta[ij]isoquinoline]-2',3',8',8'a-tetrahydro-4-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and chiral purity specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.