Description

(1S)-2',3',8',8'Aβ-Tetrahydro-5'-Hydroxy-6'-Methoxy-1'-Methylspiro[2-Cyclohexene-1,7'(1'H)-Cyclopent[Ij]Isoquinolin]-4-One is a complex spirocyclic alkaloid derivative with a defined stereochemical center. This compound is valued for its intricate molecular architecture, which serves as a critical intermediate or reference standard in advanced synthetic chemistry and pharmacological research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for developing novel active ingredients and studying structure-activity relationships.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates targeting neurological or metabolic pathways.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Medicinal Chemistry Research: Employed in lead optimization and SAR (Structure-Activity Relationship) studies due to its unique spirocyclic and isoquinoline motifs.
• Process Chemistry Development: Acts as a critical intermediate for scaling up synthetic routes in pilot plants and commercial manufacturing.
• Academic Research: Utilized in universities and research institutes for studying novel organic reactions and synthetic methodologies.
• Agrochemical Synthesis: Potential precursor for developing new crop protection agents with specific biological activity.

Basic Information

Product Name	(1S)-2',3',8',8'Aβ-Tetrahydro-5'-Hydroxy-6'-Methoxy-1'-Methylspiro[2-Cyclohexene-1,7'(1'H)-Cyclopent[Ij]Isoquinolin]-4-One
CAS No.	10214-55-8
Molecular Formula	C20H25NO3
Molecular Weight	327.42 g/mol
Synonyms	1'-Methylspiro[cyclohex-2-ene-1,7'(1'H)-cyclopent[ij]isoquinoline]-4-one, 2',3',8',8'a-tetrahydro-5'-hydroxy-6'-methoxy-, (1S)-; (1S)-1'-Methylspiro[cyclohex-2-ene-1,7'(1'H)-cyclopent[ij]isoquinoline]-2',3',8',8'a-tetrahydro-5',6'-diol 6'-methyl ether; Spirocyclic isoquinoline alkaloid derivative; (S)-enantiomer of the spiro compound 10214-55-8.
EINECS	Contact for details

Quality Control

Our (1S)-2',3',8',8'Aβ-Tetrahydro-5'-Hydroxy-6'-Methoxy-1'-Methylspiro[2-Cyclohexene-1,7'(1'H)-Cyclopent[Ij]Isoquinolin]-4-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (S)-enantiomer
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.