Description

n-(2,4-Dinitrophenyl)-D-Proline is a specialized chiral derivative of proline, featuring a 2,4-dinitrophenyl (DNP) protecting group. This compound matters as a high-purity synthetic intermediate, offering precise stereochemical control for the development of advanced pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in asymmetric synthesis, peptide chemistry, and the development of enzyme inhibitors or receptor ligands.

Application

• Pharmaceutical Intermediate: Key building block in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly those targeting proteases or requiring specific chiral configurations.
• Peptide Chemistry Research: Used as a protected amino acid derivative for the synthesis of complex peptides and peptidomimetics, where the DNP group acts as an amine protector.
• Chiral Catalyst & Ligand Development: Serves as a precursor for creating novel chiral catalysts or ligands used in enantioselective transformations.
• Biochemical Research: Employed in studies of enzyme-substrate interactions and the development of enzyme inhibitors, leveraging its specific stereochemistry and functional groups.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation in chiral analysis.

Basic Information

Product Name	n-(2,4-Dinitrophenyl)-D-Proline
CAS No.	10189-66-9
Molecular Formula	C₁₁H₁₁N₃O₆
Molecular Weight	281.22 g/mol
Synonyms	D-Proline, N-(2,4-dinitrophenyl)-; (R)-1-(2,4-Dinitrophenyl)pyrrolidine-2-carboxylic acid; N-DNP-D-Proline; D-Proline DNP derivative; N-2,4-Dinitrophenyl-D-proline; 2,4-Dinitro-N-((R)-pyrrolidin-2-ylmethyl)aniline carboxylic acid form
EINECS	Contact for details

Quality Control

Our n-(2,4-Dinitrophenyl)-D-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.