Description

Pentamethylphosphoramide is a versatile organophosphorus compound with a unique structure that imparts strong basicity and excellent solvating properties. This high-performance chemical is valued for its role as a specialty solvent and reagent in demanding synthetic and industrial processes. It is particularly sought after by manufacturers and research institutions in the pharmaceutical, agrochemical, and advanced materials sectors for applications requiring a non-nucleophilic, aprotic base.

Application

• Specialty Solvent and Reaction Medium: Used as a high-boiling, polar aprotic solvent for organometallic reactions, polymerizations, and other sensitive chemical syntheses where traditional solvents are unsuitable.
• Catalyst and Ligand in Organic Synthesis: Serves as a ligand for transition metals or as a base catalyst in various coupling and condensation reactions to improve yield and selectivity.
• Gas Scrubbing and Extraction Agent: Employed in industrial processes for the selective removal or extraction of acidic gases and specific metal ions from process streams.
• Pharmaceutical Intermediate: Acts as a key building block or reagent in the synthesis of complex active pharmaceutical ingredients (APIs) and other biologically active molecules.
• Polymer and Resin Modifier: Utilized as an additive or curing agent to modify the properties of specialty polymers, resins, and coatings.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and material science applications.

Basic Information

Product Name	Pentamethylphosphoramide
CAS No.	10159-46-3
Molecular Formula	C5H15NOP
Molecular Weight	136.16 g/mol
Synonyms	Hexamethylphosphoramide; HMPA; Hexamethylphosphoric triamide; HMPT; Phosphoric tris(dimethylamide); Tris(dimethylamino)phosphine oxide; P,P,P,P,P,P-Hexamethylphosphorous triamide; ENT 50882
EINECS	233-445-1

Quality Control

Our Pentamethylphosphoramide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets precise specifications for purity, identity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, water content, and impurity profiles to guarantee suitability for your intended application.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials. Recommended storage temperature is 2-25°C. Due to its properties as a strong base/organic solvent, ensure containers are kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.457 - 1.461
Density (20°C)	1.02 - 1.03 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.