Description

Curvularin CAS NO 10140-70-2 is a potent secondary metabolite and mycotoxin produced by various fungal species, belonging to the class of resorcylic acid lactones. This compound is of significant interest due to its notable biological activities, including phytotoxic, antimicrobial, and cytotoxic effects. It serves as a valuable reference standard and research chemical for scientists in the fields of mycology, plant pathology, and pharmaceutical discovery, enabling the study of toxin mechanisms and the development of potential therapeutic agents.

Application

• Phytotoxicity Research: Used as a model phytotoxin to study plant-pathogen interactions, herbicide mechanisms, and plant defense responses.
• Mycotoxin Reference Standard: Essential for analytical laboratories for the calibration, validation, and quality control of assays detecting curvularin in food, feed, and environmental samples.
• Antimicrobial Studies: Investigated for its activity against various bacteria and fungi, supporting research into novel antibiotic scaffolds.
• Cancer Research: Employed in biochemical and cell-based assays to explore its cytotoxic and anti-proliferative properties against various cancer cell lines.
• Biochemical Pathway Analysis: Serves as a tool compound to inhibit specific enzymes or modulate biological pathways in metabolic studies.
• Natural Product Chemistry: Used as a benchmark in the isolation, structural elucidation, and synthesis of related resorcylic acid lactones.

Basic Information

Product Name	Curvularin
CAS No.	10140-70-2
Molecular Formula	C16H20O5
Molecular Weight	292.33 g/mol
Synonyms	(+)-Curvularin; Curvularine; NSC 172033; 6-(1,3-Dihydroxy-6,8-dimethyl-4-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid; 5-(1-Carboxy-4-methyl-3-pentenyl)-3,5-dihydroxy-7-methyl-3H-isobenzofuran-1-one; Radicicol B
EINECS	Contact for details

Quality Control

Our Curvularin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.