Description

1,4,7,10-Tetraazacyclododecane Tetrahydrochloride is a high-purity, versatile macrocyclic polyamine ligand, essential for advanced coordination chemistry and pharmaceutical research. Its core value lies in its exceptional ability to chelate metal ions with high affinity and selectivity, forming stable complexes critical for diagnostic and therapeutic applications. This compound is a fundamental building block for researchers and manufacturers in the fields of magnetic resonance imaging (MRI) contrast agents, radiopharmaceuticals, catalysis, and chemical sensing.

Application

• MRI Contrast Agent Precursor: Serves as the foundational chelator (DOTA ligand) for Gadolinium(III) and other lanthanide complexes used in diagnostic imaging.
• Radiopharmaceutical Development: Key intermediate for synthesizing chelators that bind radioisotopes (e.g., 68Ga, 177Lu, 90Y) for targeted cancer therapy and PET imaging.
• Catalysis & Chemical Synthesis: Acts as a ligand to create transition metal catalysts for organic transformations and polymerization reactions.
• Chemical Sensing & Analysis: Used to develop selective sensors and analytical reagents for metal ion detection in environmental and biological samples.
• Bioconjugation & Drug Delivery: Functionalized to attach targeting molecules (antibodies, peptides) for site-specific delivery of therapeutic metal ions.
• Material Science: Employed in the synthesis of metal-organic frameworks (MOFs) and functional materials with specific magnetic or luminescent properties.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane Tetrahydrochloride
CAS No.	10045-25-7
Molecular Formula	C8H24N4·4HCl
Molecular Weight	329.13 g/mol
Synonyms	Cyclen tetrahydrochloride; 1,4,7,10-Tetraazacyclododecane tetraHCl; DOTA tetrahydrochloride; 1,4,7,10-Tetraazacyclododecane, tetrahydrochloride; Tetrahydrochloride salt of 1,4,7,10-tetraazacyclododecane; 1,4,7,10-Tetraazacyclododecane hydrochloride; 1,4,7,10-Tetraazacyclododecane, hydrochloride (1:4); 1,4,7,10-Tetraazacyclododecane, 4HCl
EINECS	233-135-1

Quality Control

Our 1,4,7,10-Tetraazacyclododecane Tetrahydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency, meeting the stringent requirements for pharmaceutical and research applications. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture from the air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Chloride Content (Titration)	Theoretical ± 1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.