Description

4-Bromobicyclo[2.2.2]octane-1-carboxylic acid is a high-purity, functionalized bicyclic organic compound featuring a bromine substituent and a carboxylic acid group on a rigid, three-dimensional scaffold. This unique structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry and materials science research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of complex drug candidates, particularly those requiring a rigid, three-dimensional core structure.
• Medicinal Chemistry Research: Used as a versatile building block for constructing compound libraries in structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Agrochemical Development: Employed in the research and development of novel pesticides and herbicides, where the bicyclic framework can impart specific biological activity.
• Ligand and Catalyst Synthesis: Acts as a precursor for creating specialized ligands or organocatalysts used in asymmetric synthesis and other catalytic processes.
• Materials Science: Utilized in the development of advanced organic materials, such as monomers for polymers with unique thermal or mechanical properties.
• Academic & Industrial R&D: A valuable reagent for fundamental organic synthesis research and the development of new synthetic methodologies in both academic and industrial settings.

Basic Information

Product Name	4-Bromobicyclo[2.2.2]octane-1-carboxylic Acid
CAS No.	1989-50-0
Molecular Formula	C9H13BrO2
Molecular Weight	233.10 g/mol
Synonyms	4-Bromobicyclo[2.2.2]octane-1-carboxylic acid; 1-Carboxy-4-bromobicyclo[2.2.2]octane; Bicyclo[2.2.2]octane-1-carboxylic acid, 4-bromo-; 4-Bromoadamantane-1-carboxylic acid (common misnomer based on structure); 4-Bromoquinuclidine-1-carboxylic acid (related bridgehead system); 4-Bromo-1-carboxybicyclo[2.2.2]octane
EINECS	Contact for details

Quality Control

Our 4-Bromobicyclo[2.2.2]octane-1-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.