Description

3,3,4,4-Tetrafluoropyrrolidine Hydrochloride is a high-value fluorinated heterocyclic building block essential for modern synthetic chemistry. This compound matters as a key precursor for introducing the tetrafluoropyrrolidine moiety, a privileged scaffold known to enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting protease inhibitors and other enzyme modulators.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorinated pyrrolidine structure can improve compound activity and environmental persistence.
• Fluorinated Building Block: Serves as a versatile reagent in organic synthesis for introducing fluorine atoms and the pyrrolidine ring system into complex molecules, enabling structure-activity relationship (SAR) studies.
• Material Science Research: Employed in the development of specialty chemicals and advanced materials, including liquid crystals and functional polymers that benefit from fluorinated components.
• Bioconjugation & Probe Development: Useful in creating labeled compounds and biochemical probes for diagnostic and research applications due to its reactive amine handle after deprotection.

Basic Information

Product Name	3,3,4,4-Tetrafluoropyrrolidine Hydrochloride
CAS No.	1810-13-5
Molecular Formula	C₄H₆ClF₄N
Molecular Weight	179.54 g/mol
Synonyms	3,3,4,4-Tetrafluoropyrrolidine HCl; 2,2,3,3-Tetrafluoropyrrolidine Hydrochloride; Pyrrolidine, 3,3,4,4-tetrafluoro-, hydrochloride; 1-Azabicyclo[3.1.0]hexane, 3,3,4,4-tetrafluoro-, hydrochloride; Tetrafluoropyrrolidine Hydrochloride; 3,3,4,4-Tetrafluoro-1-azabicyclo[3.1.0]hexane hydrochloride; 1810-13-5; NSC 196476
EINECS	Contact for details

Quality Control

Our 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.