Description

(Chloromethyl)Diphenylphosphine Oxide is a versatile organophosphorus compound that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring both a reactive chloromethyl group and a phosphine oxide moiety, makes it an invaluable reagent for constructing complex molecules and functional materials. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty polymer sectors for developing new active ingredients and performance additives.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Ligand Synthesis: Used to prepare specialized phosphine oxide ligands for catalysis and metal complexation in fine chemical production.
• Agrochemical Development: Building block for creating new herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Polymer Modification: Imparts flame-retardant properties and improves thermal stability when incorporated into engineering plastics and resins.
• Material Science Research: Employed in the development of advanced materials, including liquid crystals and organic semiconductors.
• Cross-Coupling Reactions: Serves as a functional handle in Suzuki, Heck, and other palladium-catalyzed coupling reactions to build complex aromatic systems.

Basic Information

Product Name	(Chloromethyl)Diphenylphosphine Oxide
CAS No.	1806-49-1
Molecular Formula	C13H12ClOP
Molecular Weight	250.66 g/mol
Synonyms	Chloromethyldiphenylphosphine Oxide; (Chloromethyl)diphenylphosphine P-Oxide; Diphenyl(chloromethyl)phosphine Oxide; α-Chlorobenzyl(diphenyl)phosphine Oxide; Phosphine Oxide, (chloromethyl)diphenyl-; NSC 163083; (Chloromethyl)phenylphosphinic Acid Diphenyl Ester (related structure)
EINECS	217-309-9

Quality Control

Our (Chloromethyl)Diphenylphosphine Oxide is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	95 - 105 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.