Description

4,4,4-Trifluoro-3-Hydroxy-3-Phenylbutanoic Acid is a high-value fluorinated organic building block characterized by a trifluoromethyl group and a β-hydroxy acid moiety. This unique structure makes it a critical intermediate for synthesizing advanced pharmaceuticals and agrochemicals, where the introduction of fluorine atoms can dramatically alter a compound's metabolic stability, bioavailability, and binding affinity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS drugs and anti-inflammatory agents where the trifluoromethyl group is a privileged pharmacophore.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging fluorine's ability to enhance lipophilicity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated compounds used in the electronics industry for liquid crystal displays (LCDs).
• Advanced Polymer Modification: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, and thermal stability.
• Asymmetric Synthesis Chiral Pool: The chiral center at the 3-position makes it a valuable starting material for the synthesis of enantiomerically pure compounds via chiral pool strategy.
• Fluorine Chemistry Research: An essential compound for academic and industrial research exploring new C-F bond formation reactions and the properties of fluorinated molecules.

Basic Information

Item	Details
Product Name	4,4,4-Trifluoro-3-Hydroxy-3-Phenylbutanoic Acid
CAS No.	1716-77-4
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	3-Hydroxy-4,4,4-trifluoro-3-phenylbutanoic acid; 4,4,4-Trifluoro-3-hydroxy-3-phenylbutyric acid; 3-Phenyl-3-hydroxy-4,4,4-trifluorobutyric acid; 3-Hydroxy-3-phenyl-4,4,4-trifluorobutyric acid; TFHPBA; (RS)-4,4,4-Trifluoro-3-hydroxy-3-phenylbutanoic acid; (±)-4,4,4-Trifluoro-3-hydroxy-3-phenylbutanoic acid
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-3-Hydroxy-3-Phenylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.