Description

1,3-o-Benzylideneglycerol is a versatile organic compound and a key protected glycerol derivative, serving as a crucial chiral building block in sophisticated organic synthesis. Its primary value lies in providing a stable, masked diol functionality that enables selective reactions at the remaining hydroxyl group, which is essential for constructing complex molecular architectures. This intermediate is particularly valuable for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity chiral precursors for drug discovery and fine chemical production.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, cardiovascular, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of chiral ligands used in asymmetric hydrogenation and other enantioselective transformations.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialized polymers with unique thermal or mechanical properties.
• Protecting Group Strategy: The benzylidene acetal group is widely employed in multi-step synthesis to protect 1,2- or 1,3-diols, with this compound being a convenient source.
• Fine Chemical and Flavor/Fragrance Intermediate: Utilized in the synthesis of complex natural products, flavors, and aroma chemicals.

Basic Information

Product Name	1,3-o-Benzylideneglycerol
CAS No.	1708-40-3
Molecular Formula	C10H12O3
Molecular Weight	180.20 g/mol
Synonyms	(R)-(+)-1,2-O-Benzylideneglycerol; (R)-(+)-1,2-O-Benzylidene-sn-glycerol; (R)-1,2-O-(Phenylmethylene)glycerol; 1,2-O-Benzylidene-sn-glycerol; 2-Phenyl-1,3-dioxan-5-ol; Benzylidene Glycerol; Glycerol 1,2-acetal benzaldehyde; (R)-4-(Hydroxymethyl)-2-phenyl-1,3-dioxolane
EINECS	216-964-7

Quality Control

Our 1,3-o-Benzylideneglycerol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, enantiomeric excess, and key physical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage under an inert atmosphere (nitrogen or argon), please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (R-isomer)
Melting Point	72 - 76 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.