Description

6-Bromo-4-Chloro-2-(Trifluoromethyl)Quinoline is a high-value, multi-functional halogenated quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring bromo, chloro, and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors, antiviral agents, and other biologically active heterocyclic compounds.
• Agrochemical Synthesis: Used in the development of new-generation pesticides, herbicides, and fungicides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a building block for organic semiconductors, liquid crystals, and fluorescent dyes due to its electron-deficient quinoline core.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging reagent in the design of chemical probes and activity-based protein profiling (ABPP) agents.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse compound libraries.

Basic Information

Product Name	6-Bromo-4-Chloro-2-(Trifluoromethyl)Quinoline
CAS No.	1701-28-6
Molecular Formula	C10H4BrClF3N
Molecular Weight	310.50 g/mol
Synonyms	4-Chloro-6-bromo-2-(trifluoromethyl)quinoline; 2-(Trifluoromethyl)-6-bromo-4-chloroquinoline; 6-Bromo-4-chloro-2-trifluoromethylquinoline; Quinoline, 6-bromo-4-chloro-2-(trifluoromethyl)-; 1701-28-6; 6-Bromo-4-chloro-2-(trifluoromethyl)chinolin (German); 6-ブロモ-4-クロロ-2-(トリフルオロメチル)キノリン (Japanese)
EINECS	Contact for details

Quality Control

Our 6-Bromo-4-Chloro-2-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports your R&D and scale-up processes with reliable, traceable material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.